HBO just bid farewell to one of its weirdest entities ever, when The Leftovers finally came to end on Sunday. But it won’t be long until the cable channel offers up another curiosity for us to puzzle over on Sunday nights.

It’s called Room 104 and judging by its breathless first trailer, it is way, way out there. The 12-episode anthology comes from the minds of the Duplass Brothers, whose last undertaking at HBO was the criminally underrated dramedy Togetherness.

Room 104—which tells the stories of disparate people as they pass through a single motel room—marks something of a departure for the Duplass brothers, who’ve become experts at capturing the existential malaise of getting older.

Here, it looks like they’ve channeled their inner-David Lynch for a glimpse at what seediness lurks just beneath the surface. Coming along for the ride is an eclectic cast of familiar faces and rising stars.

Among the most familiar is James Van Der Beek, who looks to have recaptured some of the manic energy that made him so watchable in The Rules of Attraction.

Orlando Jones (American Gods), Nat Wolff (Paper Towns), Transparent‘s Amy Landecker and Mae Whitman (Parenthood) also star.

“We’ve all seen stories set in seedy motels and high-class international resorts, but for years we’ve been fascinated by the funny, weird, sad, scary, absurd things going down in that corporate chain hotel near the airport,“ the brothers said last year. "That’s what Room 104 is after…finding some magic in the seemingly mundane.”

We can’t wait to check in on July 28, when Room 104 premieres on HBO. Watch the trippy first trailer below.