Television execs (and audiences for that matter) just can’t seem to get enough of mutants. Fresh off the triumph of FX’s weird and wonderful Legion, FOX is once again dipping its toes in the X-Men universe, this time with The Gifted, a new Marvel drama whose extensive first trailer debuted Monday.

The show stars Stephen Moyer and Amy Acker as a couple who must come to terms with the fact that their children are, er, gifted. Of all the directors who’ve left their imprint on Marvel’s most far-reaching franchise, none have been more impactful than executive producer Bryan Singer, who’s directed four features about the exploits of Charles Xavier and his School for Gifted Youngsters.

While The Gifted probably won’t feature any of the more mainstream X-Men (at least not at first) it will have ties to the larger X-Men mythology. “The X-Men, the Brotherhood. We don’t even know if they exist anymore,” one mutant says in the trailer. Percy Hynes and Natalie Alyn Lind star as the brother and sister who go on the run when their telekinetic abilities are discovered in a scene that makes the infamous Carrie prom scene look tame by comparison.

Along the way, they’ll meet some more established Marvel characters like Blink (Jamie Chung) and Polaris (Emma Dumont). But according to series creator Matt Nix, fans hoping to see Wolverine carve up some bad guys probably shouldn’t get their hopes up just yet. “The movies and the comics have generally started with the X-Men and encountered the world outside from the perspective of the X-Men,” Nix told CNET. “This show flips that on its head, in the sense that it doesn’t exclusively take place inside the world of people who are already X-Men and know that world.“

But Nix made sure not to crush the hopes of diehard X-Men fans hoping to see some of their favorites as the series progresses. “Suffice it to say it’s a show that contains some characters that fans will be excited about,” he said. “I can’t talk about specifics but it’s not like there are no X-Men in it.”

There’s no official premiere date set for The Gifted but Fox says we can expect it come fall. Watch the trailer below.