Playboy.com: In the movie's hotel orgy scene, you have to act with penises walking in and out of screen. What was it like to act with a penis in your face?

John C. Reilly: Oh, that's the joke of it. My character at that time has become so instantly debauched by the rock-and-roll lifestyle on the road that it becomes normal for him to be talking to people while they're in the nude, while he's on the phone. That said, it wasn't just a disembodied penis that I had to deal with. It was a guy named Tyler who was a really good sport, and he was not ashamed of his body; he was just comfortable. That made it a lot easier.

Playboy.com: But was it hard getting into the mindset of a guy who sleeps with 411 women? What's the secret to Dewey's virility?

Reilly: Viagra! [Laughs] Do you mean for me, personally, to act in those scenes? Personally, I've never even had a kissing scene in a movie before, and I had to have anonymous sex with so many different people. It was a little bit difficult, because I'm a happily married guy -- I have been for 15 years, and I have a family. But all the physical parts of acting, whether it's fighting or pretending to have sex, it all ends up feeling like dancing. You're not actually making any physical contact, other than with your mouth.

The sex scenes required some communication from the brain department to the plumbing department, but the girls were all really good sports. If anything, you gotta be a little extra formal when people were getting naked. I have a lot of respect for people that do that for a living. It takes a lot of guts. You're very vulnerable. You have to have a good sense of self-esteem. It was really good to meet Angie and Scarlett and Deanna. [Playmates Angela Little, Scarlett Keegan and Deanna Brooks were all cast in the movie.] I personally don't think that the human body is something to be ashamed of. Call me a libertarian or whatever. I really respect people that are able to celebrate their bodies in that way. They provide a great service. Playboy has provided a great service to young men for many years and we would be a much more pent-up and hostile world without it.

Playboy.com: The film's orgy scene is so over the top it's hysterical. You just had naked girls coming out of the woodwork -- guys walking buck naked across the screen.

Reilly: That's the thing about this movie people are going to be shocked to see. It's over the top, but we tried to make it realistic. We tried to make even the crazy over-the-top jokes in the movie period-correct. Those were some of the oddest conversations that Jake would have to have with actors on the set. The girls would come in willing to get naked, but you don't necessarily know what their pubic hair situation is gonna be like. If it's the 1950s, the Brazilian wax wasn't exactly popular. So on the set, the girl would be totally nude, and Jake would see she's got no carpet down there, and he'd have to say, "Do you mind putting your underwear back on? No offense, but it's not correct."

Playboy.com: It's good to see Jake's a pubic hair perfectionist. But he said you were a perfectionist about the kind of monkey you had in the movie, that you insisted on a chimpanzee.

Reilly: Yeah, Elvis had a chimp named Scatter, and I was very inspired by the idea that someone's relationships with people become so fucked up you end up feeling closest to a chimp. That says a lot about the rock star life right there.